EMAIL:orders@austropeptide.com|WhatsApp , Telegram:+18502500944 | wickr:ALEXSCHMIED

echo str_repeat(' ', 5);
-71%

AICAR 50mg

6.40$

AICAR 50MG 

per vial: 50 mg

AICAR

price is base on per vial

Important Notification: All of our products and services listed in this website are for research or production use only, not for direct human use.

5.00 out of 5
(1)
 

AICAR 50mg 

AICAR (Acadesine) Spec Sheet
Size/Unit 50 mg/vial
Quantity/Unit 1 vial
Physical Appearance White
Peptide Purity 99.6%
Molecular Formula C9H15N4O8P
Molecular Mass 338.211162
CAS NO. 2627-69-2
Storage Guidelines AICAR will remain stable at room temperature for up to 90 days. Ideally it should be stored in a freezer at or below -9C. AICAR should be refrigerated after reconstitution.

AICA-Ribonucleotide (AICAR)[edit] AICAR (5-amino-1-β-D-ribofuranosyl-imidazole-4-carboxamide), also known as ZMP, is an analog of AMP that is capable of stimulating AMP-dependent protein kinase activity (AMPK). AICAR is being researched to treat and protect against cardiac ischemic injury. If left untreated, it may lead to a myocardial infarct. Cardiac Ischemia is caused by insufficient blood flow and oxygen to the myocardium. AICAR was first used in the 1980s as a method to preserve blood flow to the heart during surgery.

Currently, AICAR has also been shown as a potential treatment for diabetes by increasing the metabolic activity of tissues by changing the physical composition of muscle. AICAR (commonly under the name Acadesine) is an analog of adenosine that enters cardiac cells to inhibit adenosine kinase and adenosine deaminase. It enhances the rate of nucleotide re-synthesis increasing adenosine generation from adenosine monophosphate only during conditions of myocardial ischemia. In cardiac myocytes, AICA-riboside is phosphorylated to AICA-ribotide (ZMP) to activate AMPK without changing the levels of the nucleotides. ZMP is able to enter the de novo synthesis pathway for adenosine synthesis to inhibit adenosine deaminase causing an increase in ATP levels and adenosine levels.

It has been shown that a brief period of coronary arterial occlusion followed by reperfusion prior to prolonged ischemia is known as preconditioning. It has been shown that this is protective. Preconditioning preceded myocardial infarction, may delay cell death and allow for greater salvage of myocardium through reperfusion therapy.

AICAR has been shown to precondition the heart shortly before or during ischemia.

AICAR triggers a preconditioned anti-inflammatory state by increasing NO production from endothelial nitric oxide synthase.

When AICAR is given 24 hours prior to reperfusion, it prevents post ischemic leukocyte-endothelial cell adhesive interactions with increased NO production.

AICAR-dependent preconditioning is also mediated by an ATP-sensitive potassium channel and hemeoxygenase-dependent mechanism. It increases AMPK-dependent recruitment of ATP-sensitive K channels to the sarcolemma causing the action potential duration to shorten, and preventing calcium overload during reperfusion.

The decrease in calcium overload prevents inflammation activation by ROS.

AICAR also increases AMPK-dependent glucose uptake through translocation of GLUT-4 which is beneficial for the heart during post-ischemic reperfusion.

The increase in glucose during AICAR preconditioning lengthens the period for preconditioning up to 2 hours in rabbits and 40 minutes in humans undergoing coronary ligation.

As a result, AICAR reduces the frequency and size of myocardial infarcts up to 25% in humans allowing improved blood flow to the heart. As well, the treatment has been shown to decrease the risk of an early death and improve recovery after surgery from an ischemic injury.

 

packagingpeptide1-2

shipping-peptide

 

  •  On time delivery 
  • Free sample 
  • 24/7/360 after sales services for all of our products 
  • Exporting to South America (Brazil, …) , Australia, Middle East , Europe (Austria, Germany, Italy,…), USA, Asia (Vietnam, India, Thailand,…), Africa 
  • The highest peptide purity more than 98%
  • HPLC and MS records for any orders 
  • Research and development our products in Austria through our experianced team 
  • More than 2 decades experiances 
  • Accept different currancies , Such as USD, EUR, AUD, CAD, JPY, TWD, AED , HKD, CNY (RMB), …
  • OEM can be accepted 

FAQ:

A peptide that I purchased recently has less powder in it than others I’ve gotten. Does this mean it doesn’t have the right MG?

Peptides due to their nature come in a variety of sizes and shapes. Normally after the lyophilization process has completed we have a peptide that is in a perfect cake. However there are times when it may break in transit or simply appear differently. This is no way effects the quality or potency of the product. It is simply an aesthetic issue. While we do try to always present a product that looks perfect, on occasion this isn’t possible. Proteins such as LR3 are very large in size and due to the requirement of a buffer will appear larger in size than a mod grf or ghrp. This is also normal.

If A Peptide Is 98% In Purity Then What Is The Remaining 2%?

The purity level indicated on a COA is simply a measurement of aminos that made it into the proper chain to form the peptide. The left over 2% are simply aminos that, for what ever reason, didn’t make it into the proper sequence.

What Are The Purity Levels Of The Peptides You Sell?

AP PEPTIDE will never sell a peptide that is less than 98% in purity from our catalog section. Many of our smaller peptide chains are well into the 99% purity range. We have manufacturing abilities that are quite often beyond the scope of smaller companies and therefore are able to achieve very high purity levels. Proteins such as IGF-1 LR3 are always receptor grade and always above 95% purity.

Two Vials Of The Same Peptide Have Different Amounts Of Powder. Does This Mean They Are Different In Milligrams?

Peptides, due to their nature, come in a variety of sizes and shapes. Normally after the lyophilization process has completed we have a peptide that is in a perfect cake. However there are times when it may break in transit or simply appear differently. This in no way effects the quality or potency of the product. It is simply an aesthetic issue. While we do try to always present a product that looks perfect, on occasion this isn’t possible.

Proteins are very large in size and due to the requirement of a buffer will appear larger in size than a mod grf or ghrp. This is also normal.

What Are Your Products Used For?

Peptides and Research serums are manufactured and sold to be used in a laboratory research setting. None of our products are intended for, nor are they manufactured for, diagnostic or therapeutic purposes in humans. Strong Peptide reserves the right to require additional verification of proper intent prior to fulfilling orders. Any orders that we feel aren’t for the specific intended purpose laid out in our Terms and Conditions will be denied.  Truthfully, if you are asking this question then you shouldn’t be ordering from AP PEPTIDES.

  1. Jhoan Rdz

    5 out of 5

    I am a repeat customer for a few reasons the most important is the excellent advice, as it can be a bit of a minefield getting so many different opinions on the forums and I really appreciated some great advice from Alex clearing up my misconceptions, good prices and they arrive quickly too, but the advice and customer service for me is invaluable.
    Plus when I was first looking to get peptides I was never sure if they were genuine and I would actually get them so really want to stick with a safe company.

Add a review

This site uses Akismet to reduce spam. Learn how your comment data is processed.

Updating ..
Your cart is currently empty.